INDOLE-3-CARBINOL (I3C) @ Hundred Deals Shopee
🥰 => Indole-3-Carbinol (I3C)
*** Indole-3-Carbinol or I3C, from cruciferous plants, i.e. cabbages, cauliflower, etc., is one of the Six Natural Anti-Cancer Super Cocktail Plant Extracts according to a research study.
The study has shown that I3C demonstrate anti-cancerous properties by inducing anti-proliferative signaling and apoptosis in cancer cells.
Download the complete information …
The Six Natural Anti-Cancer Super Cocktail Plant Extracts
🥰 => Natural Anti-Cancer Fruits & Vegetables (PDF, 528 kb filesize)
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Indole-3-Carbinol (I3C): A Powerful Compound from Cruciferous Vegetables
Indole-3-carbinol (I3C) is a naturally occurring compound found in cruciferous vegetables such as broccoli, cauliflower, cabbage, Brussels sprouts, and kale.
Over the past few decades, I3C has gained significant attention in the scientific and health communities for its potential roles in hormone regulation, cancer prevention, and overall cellular health.
What is Indole-3-Carbinol (I3C)?
I3C is formed when the enzyme myrosinase acts on glucobrassicin, a glucosinolate found in cruciferous vegetables. When these vegetables are chopped or chewed, the enzyme converts glucobrassicin into I3C and other biologically active compounds, including diindolylmethane (DIM), a metabolite with additional health benefits.
Sources of I3C
I3C is found in the highest concentrations in the following vegetables:
Broccoli
Cabbage
Cauliflower
Brussels sprouts
Kale
Collard greens
Cooking methods can influence the I3C content. Light steaming is considered the best way to preserve its potency, while prolonged boiling may degrade the compound.
Health Benefits of Indole-3-Carbinol
- Hormonal Balance
I3C is known for its role in modulating estrogen metabolism. It promotes the conversion of estrogen into less potent, non-carcinogenic forms. This action may:
Support hormonal balance in both men and women.
Reduce the risk of estrogen-dominant conditions, such as fibroids or endometriosis.
Assist in prostate health in men.
- Cancer Prevention
Numerous animal and cell studies suggest that I3C may have anti-cancer properties:
Helps detoxify carcinogens through activation of phase I and II detox enzymes in the liver.
Inhibits growth of estrogen-responsive tumors, such as some forms of breast and cervical cancers.
Induces apoptosis (programmed cell death) in cancer cells.
However, while the laboratory data is promising, human clinical trials are still ongoing, and more research is needed to fully confirm these effects.
- Antioxidant and Anti-inflammatory Properties
I3C also acts as an antioxidant, neutralizing free radicals that can damage DNA and cells. Additionally, it exhibits anti-inflammatory actions, making it potentially beneficial for conditions linked to chronic inflammation.
- Liver Detoxification
By upregulating detoxification enzymes, I3C supports the body’s natural ability to process and eliminate toxins, hormones, and other metabolic waste products efficiently.
Supplementation and Dosage
While consuming cruciferous vegetables is the best natural source of I3C, supplements are available in capsule form. Common dosages range from 200 mg to 400 mg per day, though higher doses may be used under medical supervision, especially in clinical trials for cancer treatment.
It’s important to note that I3C is unstable in the acidic environment of the stomach, where it can convert into various compounds, including DIM, which may account for many of its biological effects. For this reason, some people choose to supplement directly with DIM instead.
Safety and Side Effects
I3C is generally well tolerated, but potential side effects include:
Gastrointestinal discomfort
Skin rashes
Changes in urine color
Headaches
Long-term safety data is limited, so caution is advised, particularly for individuals with hormone-sensitive conditions or those taking medications that affect estrogen metabolism.
Pregnant and breastfeeding women should avoid I3C supplements due to lack of safety data.
Conclusion
Indole-3-carbinol is a fascinating and promising natural compound with a variety of potential health benefits—particularly in hormone balance, cancer prevention, and detoxification.
While more human studies are needed to solidify its therapeutic roles, incorporating cruciferous vegetables into your diet remains a smart, evidence-backed move for overall health.
If considering I3C supplementation, it’s best to consult with a healthcare provider to ensure safety and appropriate use.
